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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   247-251

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Cytotoxic Studies of Newer 3-(1-Benzofuran-2-Yl)-5-(Substituted Aryl) Isoxazole



Address:   Chetan M. Bhalgat1*, Sachin L. Patil2, Sandeep K. Chitale1, Krantisinha Randive1, Kumar G. Patil1 and Santosh Patil1
1Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G.Nagara- 571448, Mandya 2Principal, Mayani College of Pharmacy, Mayani- 415102, Tal: Khatav, Dist: Satara
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The 3-(1-benzofuran-2-yl)-5-(substituted phenyl) isoxazole have been synthesized by the reaction of Benzofuran chalcone with hydroxylamine hydrochloride in presence of sodium acetate in ethanol. All the compounds were synthesized by conventional method and characterized by IR, 1H NMR and mass spectral data. The new synthesized derivatives I1-I7 was evaluated for in vitro cytotoxic activity on HeLa cell lines. Compounds I1-I7 was scheduled for evaluation against full panel of human cervical cancer cell lines at the minimum seven concentrations at two fold dilutions.
KEYWORDS:
Benzofuran, isoxazole, chalcone, conventional, cytotoxic activity.
Cite:
Chetan M Bhalgat, Sachin L Patil, Sandeep K Chitale, Krantisinha Randive, Kumar G Patil, Santosh Patil. Synthesis and Cytotoxic Studies of Newer 3-(1-Benzofuran-2-Yl)-5-(Substituted Aryl) Isoxazole. Research J. Pharm. and Tech. 4(2): February 2011; Page 247-251.
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