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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   223-229

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effect of Various Grades of Hydroxypropylmethylcellulose (HPMC) on Drug Release from Naproxen Sodium Matrix Tablets



Address:   Kalyani Chithaluru1*, Ramarao Tadikonda2, Chris Vijetha.J1 and K. Kalyan Kumar Kandula3
1Department of Pharmaceutics, K.L.R. Pharmacy College, Khammam, Affiliated to Kakatiya University (K.U)
2Mohammadiya Instititute of Pharmaceutical Sciences, Khammam, Affiliated to K.U 3Actavis Pharma, Bangalore.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of the present study was to design oral sustained release matrix tablets of Naproxen Sodium using different grades of hydroxypropyl methyl cellulose (HPMC) as rate retarding polymer and study the effect of various formulation factors such as polymer proportion and polymer viscosity, effect of different diluents (lactose monohydrate, microcrystalline cellulose), effect of preparation method (direct compression, wet granulation) on the invitro release of naproxen sodium. The release kinetics was analyzed using zero order equation, first order equation, Higuchi’s square root equation and Korsmeyers-peppas equation. FTIR and DSC studies conducted for compatibility revealed that there was no interaction between drug and various excipients used in the study. In vitro release studies revealed that the release rate decreased with increase in polymer proportion and viscosity grade. MCC has more retardation of drug release than lactose monohydrate and wet granulation method has more retardation of drug release compared to direct compression. Mathematical analysis of release kinetics indicated the nature of drug release from matrix tablets was dependent on drug diffusion and polymer relaxation and therefore followed non-Fickian or anomalous release.
KEYWORDS:
Naproxen Sodium matrix tablets, hydroypropyl methyl cellulose, sustained release, influence of formulation variables.
Cite:
Kalyani Chithaluru, Ramarao Tadikonda, Chris VijethaJ, K Kalyan Kumar Kandula. Effect of Various Grades of Hydroxypropylmethylcellulose (HPMC) on Drug Release from Naproxen Sodium Matrix Tablets. Research J. Pharm. and Tech. 4(2): February 2011; Page 223-229.
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