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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   234-236

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Visible Spectrophotometric Determination of Abacavir Sulphate in Bulk Drug and Tablet Dosage Form



Address:   Prasada Rao C.H. 1*, Seshagiri Rao J.V.L.N.2, Dhachinamoorthi D.1, Lakshmi Aswini G.3 and Ashok K.1
1Dept. of Pharmaceutical Analysis, QIS College of Pharmacy, Ongole -523272, India.
2Dept. of Pharmaceutical Analysis, University College of Pharmaceutical sciences, Andhra University, Vishakapatnam -530003, India.
3Dept. of Pharmaceutical Analysis, Vagdevi College of Pharmacy, Gurazala -522415, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple visible spectrophotometric method has been developed for the estimation of abacavir sulphate in bulk and tablet dosage form. This method is based on the diazotization of abacavir sulphate with nitrous acid to form diazotized abacavir sulphate, followed by its coupling with ß-naphthol to form a red coloured chromogen which shows maximum absorption at 574.0nm and obeys Beer’s law in the concentration range of 5-20mcg/ml. This method was validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the method is reproducible and selective for the estimation of said drug.
KEYWORDS:
Visible spectrophotometry; Abacavir sulphate; β-naphthol; Validation.
Cite:
Prasada Rao CH , Seshagiri Rao JVLN, Dhachinamoorthi D, Lakshmi Aswini G, Ashok K. Visible Spectrophotometric Determination of Abacavir Sulphate in Bulk Drug and Tablet Dosage Form. Research J. Pharm. and Tech. 4(2): February 2011; Page 234-236.
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