Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   308-314

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antibacterial Activity of Ciprofloxacin Derivatives

Address:   Kumud Gupta1, Surendra Nath Pandeya1, Ashish Kumar Pathak1 and Anuradha Gupta2
1Division of Medicinal Chemistry, Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow, Pin-226002, U.P., India.
2Division of Biotechnology (M.S. Pharm), National Institute of Pharmaceutical Edu. and Research (NIPER), Ahmedabad, C/O B. V. Patel PERD Centre, SG Highway, Thaltej, Ahmedabad, Pin- 380054, Gujarat
*Corresponding Author
DOI No: Not Available

Ten Acyl hydrazine derivatives of ciprofloxacin were synthesized and evaluated for antibacterial activity in – vitro against Gram positive and Gram negative organisms. Among the synthesized compounds KSS3, KSS5, KSS7, KSS8, KSS9, were found to be the most active compounds with an MIC of 0.075 µg/ml against S. aureus, B. bronchiseptica, S. epidermis, E. coli, P. aeuroginosa and K. pneumoniae. These compounds were found to be 53.33 times more active as ciprofloxacin where as other five compounds KSS1, KSS2, KSS4, KSS6 and KSS10, were found to be 1.33 times more active as ciprofloxacin with an MIC of 3 µg/ ml. The results demonstrate the potential and importance of developing new quinolone derivatives against bacterial infection.
Benzoxazole derivatives, IR, 1H NMR and Mass spectroscopy, methyl-2- (arylideneamino)oxazol-4ylamino) benzoxazole -5-carboxylate and anti inflammatory.
Kumud Gupta, Surendra Nath Pandeya, Ashish Kumar Pathak, Anuradha Gupta, Synthesis and Antibacterial Activity of Ciprofloxacin Derivatives. Research J. Pharm. and Tech. 4(2): February 2011; Page 308-314.
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