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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   302-307

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design, Synthesis and Biological Evaluation of Methyl-2-(2-(Arylideneamino) Oxazol-4- Ylamino) Benzoxazole-5-Carboxylate Derivatives as New Antiinflammatory Agents



Address:   Nageshwar Rao Chilumula1, Srinivas Ampati2, Rajyalaxmi Gudipati2, Sarangapani Manda2 and Dayakar Gaday1*
1Departmet of Chemistry, Kakatiya University, Warangal, A.P-India, 506009
2University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P.-India, 506009
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A series of novel methyl-2-(arylideneamino)oxazol-4ylamino)benzoxazole-5-carboxylate derivatives synthesized. The structures of these compounds were established by IR, 1H NMR, 13C NMR, Mass spectral data and elemental analysis. Compounds were evaluated for their anti-inflammatory activity. Derivatives VIId and VIIe exhibited very good and almost equal anti-inflammatory activity in carrageenan-induced rat paw edema method compared with the standard drug Diclofenac Sodium.
KEYWORDS:
Drotaverine (DRT), Etoricoxib (ETR), Ratio derivative, absorption corrected.
Cite:
Nageshwar Rao Chilumula, Srinivas Ampati, Rajyalaxmi Gudipati, Sarangapani Manda, Dayakar Gaday. Design, Synthesis and Biological Evaluation of Methyl-2-(2-(Arylideneamino) Oxazol-4- Ylamino) Benzoxazole-5-Carboxylate Derivatives as New Antiinflammatory Agents. Research J. Pharm. and Tech. 4(2): February 2011; Page 302-307.
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