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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   290-293

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Novel Co-processed Super Disintegrating Agent Consisting of Crosspovidone and Sodium Starch Glycolate



Address:   Shah Dhiren P.*, Jain Vineet C., Sonani Nitesh G., Dalvadi Hitesh P., Dhimmar Hiren D.
C. K. Pithawalla Institute of Pharmaceutical Science and Research, Surat, Gujarat, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present study was designed to evaluate the co-processed super disintegrating agent consisting of sodium starch glycolate and crosspovidone. Various parameters such as bulk density, tapped density, hausner’s ratio, swelling ratio, angle of repose were assessed for co-processed super disintegrating agent. Aceclofenac tablet consisting of co-processed crosspovidone and sodium starch glycolate was prepared by direct compression method and evaluate for various quality control parameters like hardness, friability, disintegration time and dissolution rate study. Stability study of optimized batch was performed. It was observed that co-processed material is free flowing in nature as well as good compressibility which shows that material is suitable for direct compression. It was observed that the swelling ratio of co-processed material has more swelling then the single component of crosspovidone and sodium starch glycolate. It was observed that as the concentration of super disintegrating agent increases there was decrease in disintegration time. It was also observed that there was no major difference in disintegration time between crosspovidone and sodium starch glycolate when used alone. Co-processed superdisintegrant show better disintegration and dissolution rate. Tablets are stable after stability study.
KEYWORDS:
Xanthan gum, calcium sulphate dihydrate, lactose, Binder, Release retardant.
Cite:
Shah Dhiren P, Jain Vineet C, Sonani Nitesh G, Dalvadi Hitesh P, Dhimmar Hiren D. A Novel Co-processed Super Disintegrating Agent Consisting of Crosspovidone and Sodium Starch Glycolate. Research J. Pharm. and Tech. 4(2): February 2011; Page 290-293.
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