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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   273-275

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Visible Spectrophotometric Estimation of Atazanavir in Pharmaceutical Formulations



Address:   1Analytical Department, Vishnu Chemicals Limited, Jeedimetla, Hyderabad.
1,2Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003
3Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy Mount Pleasant, Road # 3, Banjara Hills, Hyderabad-500 034
.*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple accurate, rapid and sensitive methods have been developed for the estimation of Atazanavir in the pharmaceutical dosage forms. The Method-A is based on reaction of Atazanavir with Mordant Black III to form an ion-association colored complex at pH-2.4. The method B is based on the reaction of Atazanavir with Solochrome black-T to form an ion-association colored complex in the presence of Potassium Phthalate buffer system. These Methods exhibits maximum absorption at 537nm and 491nm respectively and obeys the Beer’s law in the concentration range of 5-90mcg/ml, 10-120mcg/ml respectively. The Methods have been statistically evaluated and were found to be precise and accurate. The proposed Methods are economical and sensitive for the estimation of Atazanavir in the bulk drug and in its formulations.
KEYWORDS:
UV-Visible Spectrophotometry, Atazanavir, Mordant Black III, Solochorme Black T.
Cite:
P Janaki Pathi, P Raveendra Reddy, N Appala Raju. Visible Spectrophotometric Estimation of Atazanavir in Pharmaceutical Formulations. Research J. Pharm. and Tech. 4(2): February 2011; Page 273-275.
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