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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   263-267

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antimicrobial Activity of Some Novel Hydrazinyl Quinazoline Amine Derivatives



Address:   Amarish B. Samel and Nandini R. Pai*
Department of Chemistry, D.G. Ruparel College, Senapati Bapat Marg, Mahim, Mumbai-400 016, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
2-chloro-4-aminoquinazolines 3a-b were synthesized by intramolecular cyclization of substituted formamide 2a-b in presence of phosphorus oxychloride in one pot. These were further condensed with 5-aryl/alkyl- 2-hydrazino-1,3,4-thiadiazoles 8a-e. synthesized by condensation of hydrazine hydrate with 2-chloro-5-aryl/alkyl-1,3,4-thiadiazoles 7a-e which in turn were obtained by copper mediated diazotization of 2-amino-5-aryl/alkyl-1,3,4-thiadiazoles 6a-e in acetic acid to give various 2-[2-(1,3,4-thiadiazol-2-yl)hydrazinyl] quinazolin-4-amines 9a-l. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. Newly synthesized compounds were screened for their antimicrobial activities.
KEYWORDS:
Antimicrobial activity, Quinazoline-4- amine, aryl/alkyl-1,3,4-thiadiazoles.
Cite:
Amarish B Samel, Nandini R Pai. Synthesis and Antimicrobial Activity of Some Novel Hydrazinyl Quinazoline Amine Derivatives. Research J. Pharm. and Tech. 4(2): February 2011; Page 263-267.
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