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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   167-174

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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New Technologies in Particulate Engineering for Pulmonary Delivery of Macromolecule



Address:   Pachoriya R and Sharma A
Department of Pharmaceutics, V.N.S Institute of Pharmacy, Neelbud, Bhopal (M.P.) India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
As the end organ for the treatment of local diseases or as the route of administration for systemic therapies, the lung is a very attractive target for drug delivery. Pulmonary delivery of macromolecule provides direct access to disease in the treatment of respiratory diseases, while providing an enormous surface area and a relatively low enzymatic, controlled environment for systemic absorption of medication. Macromolecular Porous microparticle possess densities sufficient small to create aerodynamic particle sizes in the range of 1-5 µm, and for deep lung delivery 1-3 µm. To impart favorable aerodynamic properties, an effervescent technology provides encapsulate drug efficiently, sustained drug release, create porous scaffold for tissue engineering application.
KEYWORDS:
Macromolecule, Porous microparticle, Effervescent agents, Mucoadhesive agent, Dry powder inhaler.
Cite:
Pachoriya R, Sharma A. New Technologies in Particulate Engineering for Pulmonary Delivery of Macromolecule. Research J. Pharm. and Tech. 4(2): February 2011; Page 167-174.
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