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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  12

Year :  2011

Pages :   1861-1864

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Sustained Release Methotrexate Microcapsules



Address:   B. Chandrasekhara Rao1*, S. Vidyadhara2, K.V. Ragahavendrarao4, K. Vanitha Prakassh1, B. Umashankar1and Srilatha1.
1Department of Pharmaceutics, S.S.J College of Pharmacy, V.N Pally, Hyderabad-500 075, India.
2Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur,A.P
3J&J Dechane Pharmaceuticals Pvt Ltd., Hyderabad, India.
Corresponding author
DOI No: Not Available

ABSTRACT:
Development of sustained release oral dosage forms is beneficial for optimal therapy regarding efficacy, safety and patient compliance. In present work an attempt has been made to formulate sustained release micro capsule of methotrexate by using polymers, which is preferably used as a cancer agent. Microcapsules were prepared using polymer ethyl cellulose and eudragit, by emulsion solvent evaporation technique. Varying concentrations of eudragit, drug, EC, are taken and three formulations were prepared. Further evaluation studies were carried out. Further work is required to stabilize the product; in-vivo studies estimate the amount of drug present in the various organs with disposition kinetics and establish appropriate dosage regimen to gauge the significant changes in the metabolism of the drug before further studies.
KEYWORDS:
Methotrexate, Microcapsules, SustainedRelease.
Cite:
B. Chandrasekhara Rao, S. Vidyadhara, K.V. Ragahavendrarao, K. Vanitha Prakassh, B. Umashankar Srilatha. Formulation and Evaluation of Sustained Release Methotrexate Microcapsules. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1861-1864.
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