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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  12

Year :  2011

Pages :   1857-1860

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Exploring the Protective Role of Water Extract of Spirulina platensis on Flutamide-Induced Lipid Peroxidation Using 4-Hydroxy Nonenal and Nitric Oxide as Model Markers



Address:   Supratim Ray*
Division of Pharmaceutical Chemistry, Dr. B C Roy College of Pharmacy and Allied Health Sciences, Bidhannagar, Durgapur, 713 206, India
Corresponding author
DOI No: Not Available

ABSTRACT:
This in vitro study was designed with an aim to evaluate free radical scavenging activity of water extract of Spirulina platensis on flutamide-induced lipid peroxidation using 4-hydroxy nonenal and nitric oxide as model markers. In this study goat liver has been used as liver source. The results suggest that flutamide could induce lipid peroxidation to a significant extent and it was also found that water extract of the Spirulina platensis has the ability to suppress the flutamide-induced toxicity.
KEYWORDS:
Flutamide, Spirulina platensis, lipid peroxidation, 4-hydroxy-2-nonenal, nitric oxide.
Cite:
Supratim Ray. Exploring the Protective Role of Water Extract of Spirulina platensis on Flutamide-Induced Lipid Peroxidation Using 4-Hydroxy Nonenal and Nitric Oxide as Model Markers. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1857-1860.
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