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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  12

Year :  2011

Pages :   1816-1818

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of Spectrophotometric Method for Efavirenz in Pure and in Film Coated Tablet Dosage Form.



Address:   Pravin Cholke*, S.Z. Chemate, R.S. Joshi, M.A. Raskar and R.L. Sawant
P.D.V.V.P.F’s College of Pharmacy, Vilad Ghat, Ahmednagar.
Corresponding author
DOI No: Not Available

ABSTRACT:
Efavirenz belongs to the class of non-nucleoside reverse transcriptase inhibitors and is indicated in the treatment of HIV infection. The aim of this study was to develop simple, sensitive, cost effective, accurate, precise and rapid ultraviolet (UV) Spectrophotometric method for the estimation of Efavirenz in pure form and its formulations. For the estimation of Efavirenz, solvent system employed was 0.1 N sodium hydroxide (NaOH) instead of methanol and wavelength of detection was 247 nm. The developed method was used to estimate the total drug content in commercially available tablet formulations of Efavirenz.
KEYWORDS:
Spectrophotometric determination, Sodium Hydroxide, Efavirenz.
Cite:
Pravin Cholke, S.Z. Chemate, R.S. Joshi, M.A. Raskar, R.L. Sawant. Development and Validation of Spectrophotometric Method for Efavirenz in Pure and in Film Coated Tablet Dosage Form. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1816-1818.
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