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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  12

Year :  2011

Pages :   1807-1808

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of RP-HPLC Method for Estimation of Citalopram Hbr



Address:   Mousumi Karpillai and Sachin Dhangar*
G.R.Y. Institute of Pharmacy, Borawan, Khargone-451001 Madhya Pradesh, India
Corresponding author
DOI No: Not Available

ABSTRACT:
A reversed phase HPLC method is developed for the determination of citalopram in pharmaceutical dosage form. Chromatography was carried out on an inertsil C18 column using a mixture of methanol and phosphate buffer (pH 3.4) and acetonitrile (55:40:5 v/v/v) as the mobile phase at a flow rate of 1.35ml/min. Detection was carried out at 254nm. The retention time of the drug was 3.741min.The method produced linear responses in the concentration range of 10-50 µg/ml of Citalopram. The method was found to be applicable for the determination of the drug in tablets.
KEYWORDS:
Citalopram, Estimation, Tablets, RP-HPLC.
Cite:
Mousumi Karpillai, Sachin Dhangar. Development of RP-HPLC Method for Estimation of Citalopram Hbr. Research J. Pharm. and Tech. 4(12): Dec. 2011; Page 1807-1808.
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