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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1721-1724

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation, Characterization and In Vitro Evaluation of Mucoadhesive Microspheres of Clarithromycin and Omeprazole



Address:   Aijaz A. Sheikh1*, K.R. Biyani1, N.M. Gawai 1, Fauziya Firdos1 and Sonali D. Ingole2
1 Department of Pharmaceutics, Anuradha College of Pharmacy, Chikhli, Maharashtra, India,
2 Department of Pharmaceutics, P.W College of Pharmacy, Yavatmal, Maharashtra, India,
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of the present investigation was to formulate and evaluate the mucoadhesive microsphere of clarithromycin and omeprazole using hydroxyl propyl methyl cellulose K4M, hydroxyl propyl methyl cellulose K100M and carbopol 971p. Microspheres were prepared by non-aqueous emulsification solvent evaporation method using liquid paraffin as a cross linking agent. The prepared microspheres were evaluated for micromeritic properties. Batch CF5 and OF5 shows the highest adhesion property i.e. 08 hrs and 7.55 hrs respectively. Likewise batch CF5 and OF5 also shows highest % drug entrapment i.e. 82% and 96.26% respectively and declared as an optimized batches. These batches were filled in 0 size capsules and evaluated for weight variation, content uniformity and % cumulative drug release.
KEYWORDS:
Helicobacter pylori, Mucoadhesive, Microspheres, Gastro retentive, Oral drug delivery system.
Cite:
Aijaz A. Sheikh, K.R. Biyani, N.M. Gawai, Fauziya Firdos, Sonali D. Ingole. Formulation, Characterization and In Vitro Evaluation of Mucoadhesive Microspheres of Clarithromycin and Omeprazole. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1721-1724.
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