2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1682-1686

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Effervescent Mixture Based Solid Dispersion a Novel Approach for Solubility Enhancement.



Address:   Shaikh Mohammed Vasim*
Allana College of Pharmacy, Azam campus, Pune-01.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Aceclofenac drug is practically water insoluble and it belongs to Biopharmaceutical classification system (class II) and its bioavailability is dissolution dependent. Due to poor aqueous solubility aceclofenac was chosen as a drug candidate to improve its solubility and bioavailability. The two different methods have been followed 1) Solid Dispersion (SD) of Aceclofenac was done by Hot Melt technique to enhance solubility and 2) Solid Dispersion with Effervescent Mixtures (EM).Hence an approach of combination of these two techniques that is preparation of effervescent mixture based solid dispersion was followed to improve the solubility and bioavailability of the aceclofenac. The Effervescent mixture based SD of formulation F11 (aceclofenac: PVP K-30: EM) was prepared by direct compression and were characterized by IR, DSC, FTIR, Stability studies and invitro drug release at pH 7.4. Effervescent mixture based solid dispersion tablet showed a percentage drug release of 96% in 15 min as compared to that of the 16% in 15 min of the marketed conventional formulation. Dissolution of drug increased by the effervescent mixture based solid dispersion and hence solubility was also increased. It is concluded that solubility of the aceclofenac was improved by effervescent mixture based solid dispersion with PVP K-30.
KEYWORDS:
Aceclofenac, Solid Dispersion, Effervescent Mixture, PVP K-30, In vitro release.
Cite:
Shaikh Mohammed Vasim. Effervescent Mixture Based Solid Dispersion a Novel Approach for Solubility Enhancement. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1682-1686.
[View HTML]      [View PDF]



Visitor's No. :   645988