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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1791-1793

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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UV Spectrophotometric Estimation of Voriconazole in Tablet Dosage Form



Address:   N. Tamilselvi*, Babikir Hassan, Fagir Babikir Fadul, Deepthi Kondapalli, Kandimalla Anusha and Dona Sara Kurian
K.M.C.H College of Pharmacy, Kalapatty Road, Kovai Estate, Coimbatore-641048.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A new, simple, specific, sensitive, rapid and economical procedure has been developed and validated for the estimation of voriconazole in its dosage form. Standard stock solution was prepared in methanol and further dilutions were carried out with same solvent. The resulting solutions were then scanned in the UV range (200-400nm) in a 10mm matched quartz cells in double beam UV-Visible spectrophotometer. The drug shows maximum absorption at 256 nm. The drug obeyed Beer’s law in the concentration range of 5-30µg/ml with molar absorpitivity of 3.951x10 4 l/mol.cm in methanol. Regression equation was found to be 0.03x-0.004 and coefficient of correlation was 0.999. The result of estimation of marketed tablet formulation was found to be 99.71±0.002 with their %RSD less than 2. Recovery studies were carried out by the addition of known amount of standard drug (80,100 and 120% of labeled claim of the tablet) to the preanalysed tablet solution. The % recovery was found to be 99.73±0.002.the intraday and interday assay result was within 2%. The methods were then validated statistically as per the ICH guidelines which yielded good results concerning range, precision, accuracy, robustness and ruggedness.
KEYWORDS:
Voriconazole, Spectrophotometry, Estimation, Beer’s law, Validation.
Cite:
N. Tamilselvi, Babikir Hassan, Fagir Babikir Fadul, Deepthi Kondapalli, Kandimalla Anusha, Dona Sara Kurian. UV Spectrophotometric Estimation of Voriconazole in Tablet Dosage Form. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1791-1793.
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