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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1777-1781

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of Stability Indicating Method for Low Content of Fenpiverinium Bromide Using a Supelcosil LC-CN Column By RP-HPLC.



Address:   R. Vijayalakshmi1 and S. Anbazhagan2
1Department of Pharmaceutical Analysis, Gautham College of Pharmacy (Affiliated to Rajiv Gandhi University of Health Sciences), R.T. Nagar Post, Bangalore, Karnataka -560032
2Karuna College of Pharmacy (Affiliated to Kerala University of Health Sciences), Irringuttur, Thirumittacode P.O. Palakad Dist. Kerala-679533.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, selective, accurate and precise RP-HPLC method has been developed for estimation of low content of Fenpiverinium bromide in their combined dosage form of Metamizole sodium and Pitofenone Hydrochloride of high content. The developed method uses Sodiumdihydrogenphosphate and Methanol (66:34%V/V) as the mobile phase with flow rate of 1ml/min at 210nm using supelcosil LC-CN column. The method was developed in terms of Linearity concentration range of 6.980-12.930 mcg/ml. For method validation, the Robustness results in range of 98.50 to 101.20% of satisfactorily results obtained. Mean recoveries of 100.23% with its RSD of 0.5% were achieved.
KEYWORDS:
Fenpiveriniumbromide, Reverse phase High-performance liquid chromatography.
Cite:
R. Vijayalakshmi, S. Anbazhagan. Development and Validation of Stability Indicating Method for Low Content of Fenpiverinium Bromide Using a Supelcosil LC-CN Column By RP-HPLC. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1777-1781.
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