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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1742-1745

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of Ophthalmic In Situ Gelling Formulation of Ciprofloxacin Hydrochloride Using Gellan Gum



Address:   Bhagat B.V.*, Hapse S.A., Mane A.R., Pagar H.J. and Wagh V.S.
P.D.V.V.P.F’s COPH, Ahmednagar (MH), NIMS University, Shobha Nagar, Jaipur (RJ)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Gellan gum, a cation sensitive polysaccharide was used in the preparation of ophthalmic in situ gelling formulation of Ciprofloxacin hydrochloride. The formulation prepared with optimized amount of gellan gum, which upon physiologically relevant concentration of sodium ions, exhibited instantaneous sol to gel transition. The formulation in gel form showed almost complete release of drug over the period 8 of hours. The formulation when subjected to accelerated stability studies showed good physical and chemical stability.
KEYWORDS:
Gellan gum, ophthalmic in situ gelling, sol-gel transition, Ciprofloxacin hydrochloride.
Cite:
Bhagat B.V., Hapse S.A., Mane A.R., Pagar H.J., Wagh V.S. Development of Ophthalmic In Situ Gelling Formulation of Ciprofloxacin Hydrochloride Using Gellan Gum. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1742-1745.
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