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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1737-1741

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Preparation and In-Vitro Evaluation of Nicardipine Hydrochloride Microcapsules



Address:   S.B. Bhanja1*, S.K. Martha1, P.K. Sahu1, A. Sahu1 B.B. Panigrahi2 and N. Shukla3
1Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore (K), Odisha.
2Hi-Tech College of Pharmacy, Bhubaneswar, Odisha
3Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Odisha
Corresponding author
DOI No: Not Available

ABSTRACT:
Nicardipine Hydrochloride microcapsules with a coat consisting of Cyclohexane and a polymer such as Ethyl cellulose were prepared by Coacervation phase separation induced by temperature change method. By Scanning Electron Microscopy, the microcapsules were found to be spherical, without aggregation, discrete and free flowing. The maximum percentage of drug content was found to be 85.4 % in formulation F1 in the drug: polymer ratio (4:1). Entrapment efficiency were found to be in the range of 82 % to 106%. The average particle size was found to be in the range of 222 µm to 389µm. Percent of loose drug on surface were found to be in the range of 4.54% to 8.76%. All the formulations showed good flowability. The in-vitro drug release for all the formulations F1 to F9 were found to be 6.9% to 18.4% drug release in first hour and 55.9 % to 98.8% drug release at the end of 12 hrs. Among the nine formulations, F7 shows maximum drug release i.e. 98.8% at the end of 12 hrs. All the formulations F1 to F9 were found to be Zero order drug release with Non Fickian diffusion mechanism. The FTIR study indicates that there was no drug interaction and compexation occur during the manufacturing process.
KEYWORDS:
Coacervation phase separation, Entrapment Efficiency, Loose surface crystals study, in-vitro drug release.
Cite:
S.B. Bhanja, S.K. Martha, P.K. Sahu, A. Sahu, B.B. Panigrahi, N. Shukla. Preparation and In-Vitro Evaluation of Nicardipine Hydrochloride Microcapsules. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1737-1741.
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