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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1725-1729

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of an Extended Release Drug Delivery System of Propafenone Hydrochloride.



Address:   Sushil J. Pawar*, Santosh Y. Nandedkar, Rajendra D. Wagh, Tanvir Shaikh and Vaibhav Jagtap
A.R. Ajmera College of Pharmacy, Dhule -424005 MS
Corresponding author
DOI No: Not Available

ABSTRACT:
The objective of present study is that to invent the formulation of Propafenone Hydrochloride as an extended release drug delivery system and to develop extended release formulation of Propafenone Hydrochloride mini tablets in capsule form by wet granulation technique using drug release retarding agents. Propafenone Hydrochloride is an antiarrhythmic agent, with a short half-life having usual dosage regimen of 425mg, twice daily. The drug is suitable for to prepare extended release tablet but in case of single unit dosage form intake of food affect activity of Propafenone Hydrochloride i.e. (Increased in high plasma level concentration and bioavailability). So, comparatively multiple unit dosage form i.e. mini tablets of Propafenone Hydrochloride administration food did not change plasma level concentration and bioavailability. The formulation design was implemented using Hydroxypropylmethylcellulose (Methocel E3 LV) as release retarding agent. The matrix component was varied using 0.5%, 1%, 2.5%, 3%, and 4.5%w/w of the total weight of the formulation. The final lubricated blends were evaluated for physico-chemical evaluation. The mini tablets were evaluated and filled into the capsule and then evaluated for in vitro release studies and drug contents. Release profile of the optimized formulations signified that, it gives satisfactory results.
KEYWORDS:
Propafenone Hydrochloride, HPMC E3 LV, Extended release, Mini tablets, Capsule.
Cite:
Sushil J. Pawar, Santosh Y. Nandedkar, Rajendra D. Wagh, Tanvir Shaikh, Vaibhav Jagtap. Design and Evaluation of an Extended Release Drug Delivery System of Propafenone Hydrochloride. Research J. Pharm. and Tech. 4(11): Nov. 2011; Page 1725-1729.
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