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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1576-1580

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Novel Simultaneous Estimation of Metformin, Glimepiride and Rosiglitazone in Tablet Dosage Form by RP-HPLC Method



Address:   Parthiban C.1*, Bhagavan Raju M.2, Sudhakar M.1
1Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maissamaguda, Dullapally, Secunderabad -14, Andhra Pradesh, India.
2Department of Pharmaceutical Chemistry, C M College of Pharmacy, Maissamaguda, Dullapally, Secunderabad- 500014 Andhra Pradesh, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A rapid RP-HPLC method was developed and validated for simultaneous estimation of metformin, glimepiride and rosiglitazone from pharmaceutical dosage forms. A sensitive chromatographic separation was accomplished on XTerra C18 (100×4.6 mm, 5µ) with mobile phase consisting of Methanol: phosphate buffer (pH 4.0 adjusted with ortho phosphoric acid) in the ratio of 75:25 v/v, at a flow rate of1.0 ml/min and eluents monitored at 239 nm. The developed method was validated in terms of accuracy, precision, linearity and limit of detection, limit of quantification, robustness and solution stability. The proposed method can be used for the estimation of these drugs in combined pharmaceutical dosage forms.
KEYWORDS:
Simultaneous estimation, Metformin, Glimepiride, Rosiglitazone.
Cite:
Parthiban C., Bhagavan Raju M., Sudhakar M. A Novel Simultaneous Estimation of Metformin, Glimepiride and Rosiglitazone in Tablet Dosage Form by RP-HPLC Method. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1576-1580.
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