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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1547-1550

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Qualitative Determinations of Steroids in Face Cream Formulation by Fourier Transform Infrared Spectrometry



Address:   Agarwal Alka1*, Ashawat M.S.1, Sharma K.1, Bele D2 and Singhvi I.J1
1Pacific College of Pharmacy, Udaipur (Raj.)
2Charak Institute of pharmacy, Mandleshwar, Khargone (M.P.)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Topical steroid application is associated with adverse effects especially if they are used incorrectly. The risk of most of the side effects depends on the strength of the steroid, the length of application, the site treated, and the nature of the skin problem. In present investigation, randomly selected cosmetic cream formulations (According to the ingredients mentioned on the label with none of the information about steroidal components) of repute brands (Users choice) from market. All procured and selected formulations were coded as (M1-M18) for the purpose of psychometric, physicochemical and chemical analysis. The results of chemical analysis showed that, among 18 cream formulations eight formulations were found to be positive for presence of steroids. After the chemical analysis positive selected 08 (M2, M4, M6, M7 , M8, M13, M16, M18) decoded formulations were further selected for authentic specific qualitative analysis by using a zinc selanium Fourier transform infrared spectroscopy, which was used for the determination of steroidal adulteration in cosmetics cream formulations and obtained IR spectra were compared with standard Prednisolone steroidal preparation. From the result of IR spectra it was evident that many marketed formulation which promises instant fairness, glowing, brighten skin may have a dreadfully negative and serious side effect on the skin due to presence of steroid.
KEYWORDS:
Steroids, Inflammation, Cream formulations, Psychometric, Physicochemical, IR spectra.
Cite:
Agarwal Alka, Ashawat M.S., Sharma K., Bele D, Singhvi I.J. Qualitative Determinations of Steroids in Face Cream Formulation by Fourier Transform Infrared Spectrometry. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1547-1550.
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