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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1542-1546

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of Reverse Phase Liquid Chromatographic Methods for the Determination of Acebrophylline in Capsule Form.



Address:   Mohit D. Bauskar*, Prafulla Sonawane, Santosh Y. Nandedkar, Rajendra D. Wagh, Tanvir Shaikh and Vaibhav Jagtap
A. R. Ajmera College of Pharmacy, Dhule -424005
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A RP-HPLC method used for determination of acebrophylline in capsule was developed. Determination of acebrophylline in capsule was conducted by using RP-HPLC method with UV-Spectrophotometric detector at 240nm.Standards for calibration graph ranging from 200 to 600 µg/ml from stock solution. The proposed method was accurate with 98.7% recovery value and precisied with 0.902 relative standard deviation. These results were compared with that of standards operated with same RP-HPLC method. A reverse phase HPLC method with C18 column with ammonium orto-phosphate (0.01M)-acetonitrile-methanol(65:25:10)(pH- 7)mobile phase was used and UV-detector was set to 240nm. Results obtained of test solution was compared to that of standard solution by using RP-HPLC.
KEYWORDS:
Reverse phase liquid chromatography, Acebrophylline, Acefylline, Ambroxol.
Cite:
Mohit D. Bauskar, Prafulla Sonawane, Santosh Y. Nandedkar, Rajendra D. Wagh, Tanvir Shaikh, Vaibhav Jagtap. Development and Validation of Reverse Phase Liquid Chromatographic Methods for the Determination of Acebrophylline in Capsule Form. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1542-1546.
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