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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1513-1514

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Dendrimers as Therapeutic Nano-Devices: A Review



Address:   Mohit Batra*, Rahul Nainwani, Nitin Mishra, Pradeep Guleria and Amit Jain
Department of Pharmaceutics, Mahatma Gandhi College of Pharmaceutical Sciences, Sitapura, Jaipur (Raj.)
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Dendrimer is described as NANO-DEVICE, with a regular and highly branched three dimensional architecture. They consist of three major architectural components: core, branches, and end groups. First discovered in the early 1980’s by Donald Tomalia. A dendron usually contains a single chemically addressable group called the focal point.These hyperbranched molecules were called dendrimers Dendritic molecules are characterized by structural perfection. At the same time, Newkome’s group independently reported synthesis of similar macromolecules. They called them arborols from the Latin word ‘arbor’ also meaning a tree. The uniqe properties of dendrimers such as uniform size, high degree of branching, water solubility, multivaelency, well defined molecular weight it’s important for biological activity and drug delivery application. These properties are important in pharmaceutical, nano technology and medicinal chemistry particularly. In addition nano particles drug delivery systems are the popular once as are able to increase selectivity and stability of therapeutic agents.
KEYWORDS:
Dendrimers as Therapeutic Nano-Devices.
Cite:
Mohit Batra, Rahul Nainwani, Nitin Mishra, Pradeep Guleria, Amit Jain. Dendrimers as Therapeutic Nano-Devices: A Review. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1533-1541.
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