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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1633-1636

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation Development and Evaluation of Silymarin Gel

Address:   Karanje Abhijit Sampatrao1, Kandale Jitendra Bhalchandra*, Jadhav Ravindra2, Patil Manohar3
1Allana College of Pharmacy, Azam Campus, Camp, Pune.
2Deputy General Manager, M. J. Biopharm Pvt. Ltd. Taloja Navi-Mumbai.
3M. MS. College of Pharmacy, Thergaon, Chinchwad, Pune.
*Corresponding Author
DOI No: Not Available

The present work represents topical gel formulation of Silymarin obtained from the seeds of plant Silybum marianum (L.) Silymarin is mixture of flavolignan. It consists of silybinin, silydianin, silychristin and isosilybinin. Silymarin is used as Hepatoprotective from ancient time apart from it is used as antioxidant, anti-inflammatory, anti-fibrotic, immunomodulatory and liver regenerating action. It also used clinically in liver disease, viral hepatitis, amanita mushroom poisoning, neuroprotective and neurotropic action. The various formulation of silymarin is available like tablet, capsule, suspension, syrup in market. The present aim of the study to develop silymarin gel and check antifungal activity. By using methanol as co-solvent and the Carbopol is used as gel forming agent and methyl Paraben and Propyl Paraben as preservative. The glycerin as humectants and Tween 80 used as surfactant. Gel are subjected to various physicochemical parameters such as pH, drug content, spreadability, viscosity, in vitro drug release was carried out in phosphate buffer (pH 6), primary skin irritation test and antifungal activity was checked. The stability study was done as per the ICH guidelines. The drug content, pH, spreadability of the formulation was found to be 96.6%, 6.8, 25.45gm.cm/sec respectively. From the rheogram it is concluded that gel shows pseudoplastic flow property. It shows maximum drug release 96.30% over a period of 3h.The formulation did not show acute skin irritancy.
Silymarin, Gel, Anti-fungal activity,
Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar. Formulation Development and Evaluation of Silymarin Gel. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1633-1636.
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