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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1521-1525

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Interaction of Lornoxicam with Natural Cyclodextrin in Solid and Solution State



Address:   Patil A. L.1* and Patil S. S.2 1Government College of Pharmacy, Karad, MS, India. 2Ashokrao Mane College of Pharmacy, Peth Vadgaon, MS, India. *Corresponding Author
DOI No: Not Available

ABSTRACT:
The solid state properties and dissolution behaviour of Lornoxicam (LX) with ß-cyclodextrin (ßCD) were investigated. The binary system of LX with ßCD was prepared by the kneading method. Drug-cyclodextrin interactions in solution state were investigated by the phase solubility analysis and saturation solubility study as per Higuchi and Connors. Phase solubility diagram allowed the determination of association constant between LX and ßCD and showed stability constant value 401 M-1 suggesting drug is having sufficient affinity towards ßCD cavity and formation of stable inclusion complex. As the concentration of ßCD increases, solubility of pure drug increases showing AL type of phase solubility curve. Differential scanning calorimetry, Fourier transformation infrared spectroscopy and powder X-ray diffractometry study were used to study the solid state properties of all binary systems. The results indicate partial interaction of the drug with ßCD in the physical mixture and complete interaction in the kneaded complex. Saturation solubility study revealed that solubility of the inclusion complex were enhanced to several extent compared to pure drug whereas dissolution properties of inclusion complex were evaluated according to the USP type II paddle apparatus. The dissolution rate of LX-ßCD inclusion complex was notably increased as compared to pure drug as well as its physical mixture. The inclusion complex showed 90% drug released in less than 10 min.
KEYWORDS:
lornoxicam, βCD, stability constant, kneading method, dissolution study, saturation solubility.
Cite:
Patil A. L., PatilS. S. Interaction of Lornoxicam with Natural Cyclodextrin in Solid and Solution State. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1621-1625.
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