List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1618-1620

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

A Study on the Effect of Centella asiatica on Experimentally Induced Inflammatory Bowel Disease in Albino Rats.



Address:   Mangala Lahkar and Pradumna Pathak*
Department of Pharmacology, Gauhati Medical College Hospital, Guwahati-781032, Assam, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In this study we have investigated the effect of Centella asiatica methanolic extract on acetic acid induced inflammatory bowel disease in albino rats. Total 36 albino rats were taken for the study and divided into four groups (I, II, III, IV) and three subgroups (IVa, IVb, IVc). Group I (control) and Group II (control colitis) received normal saline. Group III received sulfasalazine 360 mg/kg. Group IVa, IVb, IVc received Centella asiatica methanolic extract of 50, 100 and 200 mg/kg dose respectively. All animals of above groups were fed orally for 5 days. After 5 days colitis was induced by administering 1ml of 4% acetic acid transrectally. Animals were sacrificed after 48hours of colitis induction and 10 cm colon segment was resected. Colon was weighted and examined morphologically and histopathologically. Centella asiatica methanolic extract at doses of 100mg/kg and 200mg/kg showed significant (P<0.05) improvement in histopathological scoring.
KEYWORDS:
Centella asiatica, acetic acid, inflammatory bowel disease, sulfasalazine, colitis
Cite:
Mangala Lahkar, Pradumna Pathak. A Study on the Effect of Centella asiatica on Experimentally Induced Inflammatory Bowel Disease in Albino Rats. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1618-1620.
[View HTML]      [View PDF]



Visitor's No. :   188535