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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1591-1592

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Visible Spectrophotometric Methods for Determination of Olanzapine from Tablet Formulation



Address:   Indrajeet Singhvi*
Pacific College of Pharmacy, Pacific Hills, Pratap Nagar Ext., Airport Road, Debari, Udaipur (Rajasthan) -313003.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple and sensitive visible spectrophotometric methods have been developed for the determination of Olanzapine form Pharmaceutical tablet dosage form. Developed methods are based on formation of chloroform extractable ion pair colored complex of drug with Cosneasie Brilliant Blue R (Method A) and Methyl orange (Method B). The extracted complex formed in method A and B showed absorbance maxima at 596.0 nm and 411.0 nm and linearity was observed in concentration range of 25-150 µgm/ml and 0-250 µgm/ml of olanzapine respectively. The results of analysis were validated statistically and by recovery studies.
KEYWORDS:
Olanzapine, Cosneasie Brilliant Blue R, Methyl orange.
Cite:
Indrajeet Singhvi. Visible Spectrophotometric Methods for Determination of Olanzapine from Tablet Formulation. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1591-1592.
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