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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   66-71

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues



Address:   Theivendren Panneer Selvam1* and Palanirajan Vijayaraj Kumar2
1Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510,
Andhrapradesh, India. 2School of Pharmacy, UCSI University, Jalan Menara Gading, 56000 Cheras, Kuala Lumpur, Malaysia.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
As series of heterocycles, 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline 6a-o derivatives were synthesized and tested for Antihyperglycemic activity. Their antihyperglycemic activity was evaluated by Streptozotocin (STZ) and Sucrose-loaded (SLM) model. All the newly synthesized compounds chemical structures were confirmed by IR, 1H-NMR, mass spectroscopy and elemental analyses. The results of studies indicate that the compounds 6a, b, d, j, o displayed signi?cant reduction in blood glucose level in streptozotocin and sucrose loaded rat models.
KEYWORDS:
Thiazolo quinazoline, Thiazolo quinazoline phenyl hydrazone, Aromatic aldehydes substitution, Benzylidine thiazolo quinazoline phenyl hydrazone, Antihyperglycemic activity.
Cite:
Theivendren Panneer Selvam, Palanirajan Vijayaraj Kumar. Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues. Research J. Pharm. and Tech. 4 (1): January 2011; Page 66-71.
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