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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   43-46

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Failure of Functionality of Coated Pellets into Tablets – Problems and Solutions



Address:   Naik J.B1*, Mokale V.J.1, More D.B1, Bari M.M2, Chavhan R.B2 and More B.B.3
1U. D. C. T., North Maharashtra University, Jalgaon, 425001 [M.S.]
2Shree Sureshdada Jain Institute of Pharmaceutical Edu. and Research, Jamner, Dist-Jalgaon, 424206 [M.S.]
3Modern College of Pharmacy (For Ladies), Borhadewadi, Moshi, Pune 411044 [M.S.]
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Conventionally, single unit oral drug delivery system is being used to achieve controlled or delayed release by coating the tablets as per delivery pattern. But this system is associated with some serious problems such as dose dumping caused by rupturing the coat of the tablets. Recent trend in formulation technology is the multiparticulate oral drug delivery system, in which the pellets are either coated with hydrophilic or hydrophobic polymers. The coated pellets so formed are either filled into hard gelatin capsule or compressed into tablets. Hard gelatin capsule are prone to tempering and have high production cost, however tablets shows combined clinical advantage of multiparticulate system with cost effectiveness. But the problems associated with compression of coated pellets in to tablets are failure of functionality of coating. In order to avoid failure of functionality of coated pellets, the optimization of various formulations and processing variables is required. Present work focuses the various formulation variable posing challenges in pelletization and in subsequent compression along with strategies to overcome the failure of functionality of coated pellets into tablets.
KEYWORDS:
Polymers, formulation variable, pelletization, compression, drug delivery.
Cite:
Naik JB, Mokale VJ, More DB, Bari MM, Chavhan RB, More BB. Failure of Functionality of Coated Pellets into Tablets – Problems and Solutions. Research J. Pharm. and Tech. 4 (1): January 2011; Page 43-46.
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