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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   109-112

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Determination of Nebivolol and Amlodipine in Combined Dosage Form by Derivative Spectrophotometry



Address:   Samixa R. Patel1*, Shweta M. Patel2, Jignesh I. Patel3 and Paresh U. Patel2
1Atmiya Institute of Pharmacy, Department of Pharmaceutical Chemistry, ‘Yogidham Gurukul’, Kalawad Road, Rajkot-384005.Gujrat, India.
2S.K. Patel Colleges of Pharmaceutical Education and Research, Ganpat Vidyanagar, Kherva, Mehsana-382711, Gujarat, India.: 3B K Modi Govt Pharmacy Colleges. Polytechnic Campus, Bhavnagar Road, Rajkot-360 003.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Simple and accurate method to determine Nebivolol and Amlodipine, in tablet dosage form, was developed and validated using Derivative Spectrophotometry. Derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first-order derivative spectra were obtained at N = 1 (scaling factor), ?? = 2.0 nm, and determination was performed at 226.5 nm (ZCP of Amlodipine) for Nebivolol and 245 nm (ZCP of Nebivolol) for Amlodipine over the concentration range of 10-70 µg/mL for both drugs with mean recovery of 100.2 ± 1.25 % and 100.1 ± 1.38 % for Nebivolol and Amlodipine, respectively. Method was validated, and the results were compared statistically. They were found to be simple, sensitive, accurate, precise, reproducible and economical. The method was successfully applied for the determination of Nebivolol and Amlodipine in tablet dosage form without any interference from common excipients.
KEYWORDS:
Nebivolol, Amlodipine, Derivative spectrophotometry, zero crossing point.
Cite:
Samixa R. Patel, Shweta M. Patel, Jignesh I. Patel, Paresh U. Patel. Simultaneous Determination of Nebivolol and Amlodipine in Combined Dosage Form by Derivative Spectrophotometry. Research J. Pharm. and Tech. 4 (1): January 2011; Page 109-112.
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