List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   4

Issue No. :  1

Year :  2011

Pages :   101-104

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Development of Granisetron Hydrochloride Fast Dissolving Tablets: Comparative Evaluation of Superdisintegrating Agents



Address:   Ashish A. Heda*, Dipak D. Gadade, Nitin D. Jagdale, Nagoji M. Shinde and Prashat K. Puranik
Govt. College of Pharmacy, Vedant Road, Osmanpura, Aurangabad. (M.S.) India. 431005
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The purpose of study was development of fast dissolving Granisetron Hydrochloride (GRA) tablets using suitable disintegrating agent. Comparative effect of incorporation of superdisntegrants and conventional disintegrant at same concentrations, on disintegration and dissolution was studied. The superdisintegrants used were sodium starch glycolate (SSG) and Kyronâ T-314 (Polacrillin potassium) while sodium alginate (SA) was used as representative conventional disintegrant. The tablets were prepared by wet granulation method. The disintegration times were lower and dissolution profile of GRA was comaparatively better with the batches containing SSG compared to other disintegrating agents. The granisetron tablets with 3% SSG shows lower disintegration time than Kyronâ T-314 and SA.
KEYWORDS:
Granisetron Hydrochloride, sodium starch glycolate, Kyronâ T-314, sodium alginate, fast dissolving tablet.
Cite:
Ashish A Heda, Dipak D Gadade, Nitin D Jagdale, Nagoji M Shinde, Prashat K Puranik. Development of Granisetron Hydrochloride Fast Dissolving Tablets: Comparative Evaluation of Superdisintegrating Agents. Research J. Pharm. and Tech. 4 (1): January 2011; Page 101-104.
[View HTML]      [View PDF]



Visitor's No. :   174282