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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Polymeric Transdermal Drug Delivery Films of Iso-Sorbide Dinitrate.



Address:   1K.L.E.Society’s College of Pharmacy, Gadag, Karnataka. 2S.J.M. College of Pharmacy, Chitradurga, Karnataka.
DOI No: Not Available

ABSTRACT:
Matrix type of polymeric transdermal drug delivery films of Iso-Sorbide dinitrate (ISDN), an anti-anginal agent were formulated by using ethyl cellulose, as a film forming polymer, polyethylene glycol-4000(PEG-4000) and dibutyl phthalate as plasticizers. The transdermal films were evaluated for physicochemical properties like tensile strength, folding endurance, thickness uniformity, percentage elongation, drug content uniformity. In-vitro drug release rate was studied through excised rat’s abdominal skin using Keshary-Chein diffusion cell. It was found that the increase in the PEG-4000 ratio with the polymer, increases permeability properties of the polymeric films. The preformulation studies indicate that the polymer and drug are compatible. The drug release from matrix films was found to be of zero-order kinetics. The primary skin irritation tests were found to be negative or non-significant.
KEYWORDS:
Iso-sorbide dinitrate (ISDN), Transdermal therapeutic system (TTS), Ethyl cellulose (EC), skin irritation.
Cite:
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