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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Solubility Enhancement of Pioglitazone by Using Poloxamer (188 and 407) with the Help of Kneading Method



Address:   Department of Pharmaceutics, Smt. B.N.B. Swaminarayan Pharmacy College, Salvav, NH – 8, Vapi – 396191, Gujarat.
DOI No: Not Available

ABSTRACT:
Pioglitazone is a poorly water-soluble (BCS class II) antidiabetic drug. Due to the poor water solubility of this drug, its bioavailability is dissolution rate-limited. The purpose of this study was is to increase the solubility of Pioglitazone(PG) in aqueous media by inclusion complex (IC) technique with Poloxamer (PXM) 188 and Poloxamer (PXM) 407 by using the kneading method. The PG-PXM inclusion complex system was characterized by Differential scanning calorimetry (DSC), X-ray powder diffraction (XRD) analysis, Fourier transform-infrared spectroscopy (FT-IR) and Scanning electron microscopy (SEM), and in vitro dissolution studies. No chemical interaction was found between PG and PXM 188 or PXM 407. The results from DSC, XRD and SEM studies show that PXM 188 or PXM 407 inhibits the crystallization of PG. The ICs prepared in this study were found to have better dissolution rates in comparison to intact PG and physical mixture of PXM 188 or PXM 407. It was found that the optimum weight ratio for drug: Carrier is 1:6 for PXM 188 and 1:6 for PXM 407
KEYWORDS:
Pioglitazone, kneading, poloxamer, inclusion complex
Cite:
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