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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validated Spectrophotometric Determination of Prulifloxacin in Tablet Dosage Form

Address:   Department of Pharmaceutical Chemistry, SKB College of Pharmacy, New Kamptee, Nagpur, Maharashtra-441002.
DOI No: Not Available

Two simple, accurate and precise UV-Spectrophotometric methods have been developed and validated for the estimation of Prulifloxacin in pharmaceutical tablet. Method I was based on Spectrophotometric measurement of Prulifloxacin at absorption maxima at 272.4 nm and Method II area under curve was applied for analysis of Prulifloxacin in the wavelength range 264.0 to 277.2 nm. The drug was found to obey Beer’s -Lambert’s law obeyed in the concentration range of 5-25 µg/mL and the correlation coefficients were found to be 0.999 for both methods. The Percent estimation of the drug was found nearly 100 % for both the methods. The percent recoveries were found to be 100.37% for method I and 100.64% for method II representing accuracy of the methods. Validation of the proposed methods was carried out for its accuracy, precision, linearity, ruggedness according to ICH guidelines. The limit of detection was found to be 0.8 for both the methods and the limit of quantitation was found to be 2.4 for method I and 2.42 for method II. The developed methods were also compared statistically using unpaired t-test by Welch Correction. The proposed methods can be successfully applied in routine work for the determination of Prulifloxacin in bulk and pharmaceutical tablet dosage form.
Prulifloxacin, UV spectroscopy, Absorbance Maxima Method, Area under Curve Method.
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