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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Analgesic Activity of 2-Hetero Substituted -4-Quinazolinones



Address:   Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India.
DOI No: Not Available

ABSTRACT:
Analgesic activity of newly synthesized series of 2-heterosubstituted-4-quinazolones (NN, NP, NC, NNB, NPB, NCB) were studied in mice. The analgesic activity was carried out at healthy male Swiss albino mice by writhing method and tail immersion method. Aspirin (150mg/kg p.o) and pentazocin (10mg/kg i.p) were used as positive controls for writhing and tail immersion method respectively. The synthetic compounds were administered orally in the dose of 30mg/kg, 90mg/kg as 1% CMC suspension. Results indicate that statistically significant reduction was obtained at 30mg dose level for compounds NP, NPB and NC by writhing Method. Their p value less than 0.05.
KEYWORDS:
Quinazolinone; analgesic activity.
Cite:
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