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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Estimatiion of Nevirapine Anhydrous Bulk Formulation by Using IR, RP-HPLC, GC Methods



Address:   1Department of Pharmaceutical Chemistry, St. Ann’s College of Pharmacy, Nayunipalli Village, Vetapalem Mandal, Chirala, Andhra Pradesh, India-523187 2Department of Pharmaceutical Chemistry, Siddhartha Institute of Pharmaceutical sciences, Jonnalagadda,
DOI No: Not Available

ABSTRACT:
The non nucleoside reverse transcriptase inhibitor Nevirapine (NEV), formulating sample is analyzed with instruments Infrared spectroscopy (IR), Reverse phase High performance liquid chromatography (RP-HPLC) and Gas chromatography (GC), the type of functional groups present in the NEV sample was analyzed with IR, the concentration of Nevirapine compounds NEV A, B and impurity-1 in the formulating nevirapine sample and the assay of nevirapine was done with HPLC with retention time greater than 5 and presence of residual solvents such as Dichloro methane, Chloroform, Dimethyl formamide, O-xylene was estimated with GC, the loss on drying and residue on ignition as 0.14 and 0.04 % w/w respectively.
KEYWORDS:
Nevirapine anhydrous, IR, RP- HPLC, GC.
Cite:
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