List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation Theophylline Floating Tablets and the Effect of Citric Acid on Release.

Address:   Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, Tumkur, Karanataka
DOI No: Not Available

The objective of this research work was to formulate and evaluate the floating drug delivery system containing theophylline as a model drug. Theophylline tablets were prepared by granulation method incorporating Methocel as swelling polymer, sodium bicarbonate, as gas generating agent, citric acid as release rate enhancer and excipients such as Magnesium stearate and lactose. Dissolution profiles were studied in medium 0.1N Hcl. The influence of variables like polymer type, citric acid on theophylline release profile was studied. The release mechanisms of theophylline from floating tablets were evaluated on the basis of Peppas’s model. The ‘n’ value of all the formulations ranges from lowest 0.752 to highest 0.960 which was in the range of 0.4510 hrs. Based on the evaluation results, S3 formulation was selected as the best formulation and was checked for stability at different temperatures 25ºC / 60% RH, 35ºC / 65% RH and 40ºC / 75% RH. These results indicated that the selected formulation was stable. The drug release profile of the best formulation was well controlled and uniform throughout the gastrointestinal tract. Scanning electron microscopy (SEM) study represents the formation of gel structure. Different excipients were tested for their compatibility with theophylline such as FT-IR and DSC studies, which revealed that there is no chemical interaction occurred with other excipients.
Floating drug delivery systems (FDDS), Compatibility, FT-IR, Scanning electron microscopy (SEM), Differential scanning colorimetry (DSC), Theophylline, citric acid.
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