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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1260-1264

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Effervescent Floating Tablet of Domperidone Maleate



Address:   Nikhil M. Mahajan*, Pravin D. Telgote , Nitin A. Chandekar, Santosh G. Shep, Atish R. Sawant, C.K. Gadewar and A.V. Chandewar
P. Wadhwani College of Pharmacy, Yavatmal.
*Corresponding Author
DOI No:

ABSTRACT:
Domperidone Maleate has peripheral dopamine receptor blocking properties. It is used in the treatment of vomiting. Domperidone Maleate effervescent floating tablets were developed in ten different formulations (B1 to B10) by employing different grades of polymers and effervescent agents such as sodium bicarbonate and citric acid. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution studies, dissolution parameters and drug released mechanisms.B10 formulation showed maximum floating time of 24 hours and gave slow and maximum drug release of Domperidone Maleate spread over 24 hours. Finally the tablet formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.
KEYWORDS:
Domperidone Maleate, Effervescent floating tablet, Buoyancy.
Cite:
Nikhil M. Mahajan, Pravin D. Telgote , Nitin A. Chandekar, Santosh G. Shep, Atish R. Sawant, C.K. Gadewar, A.V. Chandewar. Formulation and Evaluation of Effervescent Floating Tablet of Domperidone Maleate. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1260-1264.
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