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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1235-1237

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Antimicrobial Activity of Some Benzothiazolyl Pyrazolone Derivatives



Address:   Ameya G. Yadav, Vrushali N. Patil, S.V. Athlekar, A.S. Bobade, L.S. Patil and Abhay Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012.
*Corresponding Author
DOI No:

ABSTRACT:
A series of 2-(1H-Benzothiazol-2-ylmercapto/amino)-N-[1,5-dimethyl-2-(substituted phenyl)-3-oxo-2,3-dihydro-1H-pyrazol-4-yl] acyl amines (5a-o) have been synthesized. These structures are determined by the elemental analyses and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.
KEYWORDS:
amino benzothiazole, anti–bacterial, anti–fungal, Mercapto benzothiazole, Pyrazolone.
Cite:
Ameya G. Yadav, Vrushali N. Patil, S.V. Athlekar, A.S. Bobade, L.S. Patil, Abhay Chowdhary. Synthesis and Antimicrobial Activity of Some Benzothiazolyl Pyrazolone Derivatives. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1235-1237.
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