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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1205-1208

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablet of Ranitidine Hydrochloride.



Address:   Jagtap P.C., Awargaonkar A.V., Kuchekar S.B. and Bhise K.S.*. Department of Pharmaceutics, MCE Society‚Äôs Allana College of Pharmacy, Azam Campus, Camp Pune-411001, Maharashtra, India.. *Corresponding Author
DOI No:

ABSTRACT:
In the present study controlled porosity osmotic pump system (CPOP) has been developed in the presence of different channeling agents in the coating. Ranitidine hydrochloride was chosen as a model drug due to its short half life. The effect of osmogen (sodium chloride) concentrations on the in-vitro release of drug was examined. Cellulose Acetate (CA) was used as a semi permeable membrane. It was found that the rate of drug release increased with change in osmogen concentration due to increased water uptake and hence increased driving force for drug release. The presence of pore forming agents rendered the desired zero order drug release for the period of 10-12 h. The optimized formulations were stable for three months when subjected to stability studies as per ICH guidelines.
KEYWORDS:
Osmotic System, Pore former, Drug release.
Cite:
Jagtap P.C., Awargaonkar A.V., Kuchekar S.B., Bhise K.S.. Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablet of Ranitidine Hydrochloride. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1205-1208.
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