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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1185-1188

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Estimation of Esomeprazole in Bulk and Tablet Dosage Form by Use of Planar Chromatography

Address:   S.A. Gosavi*1, G.B. Bhavar1, S. B. Chepurwar2, A. A. Shirkhedkar2, S. B. Bari2 and S. J. Surana2
1Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Dist: Ahmednagar, (M. S.), India, 423603.
2Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Shirpur, Dist: Dhule, (M.S.), India, 425405
*Corresponding Author

A simple, rapid, and reliable HPTLC method has been established for determination of Esomeprazole magnesium trihydrate (ESO) in tablets. Identification and determination were performed on 10 cm × 10 cm aluminum backed silica gel 60 F254 TLC plates, previously washed with methanol and using ethyl acetate: ammonia, 8: 0.8 (v/v) as mobile phase. Detection was performed at 301 nm. Calibration plots were linear in the range 100–500 ng/spot for Esomeprazole magnesium trihydrate with correlation coefficients, r, 0.9992. The suitability of this HPTLC method for quantitative determination of compound was proved by validation in accordance with the requirements of ICH guidelines. The method was used for determination of the compound in commercial pharmaceutical dosage forms. The method is simple, reproducible, and accurate and is a more effective option than other chromatographic techniques in routine quality control.
HPTLC, Pharmaceutical dosage forms, Esomeprazole magnesium trihydrate.
S.A. Gosavi, G.B. Bhavar, S. B. Chepurwar, A. A. Shirkhedkar, S. B. Bari, S. J. Surana. Estimation of Esomeprazole in Bulk and Tablet Dosage Form by Use of Planar Chromatography. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1185-1188.
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