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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1144-1147

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Study of Some 1, 2, 4-Triazole derivatives

Address:   Yogesh Jadhav, Rajeev Varma, Vrushali Patil, A. S. Bobade*, S. V. Athlekar and Abhay Chowdhary
Dept. of Chemotherapy, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai-400012
*Corresponding Author

The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K2CO3 followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS2 and KOH gave potassium salt of thiosemicarbazide which on reaction with excess of hydrazine hydrate in ethanolic medium form 3-(3-pyridoxymethyl)-4-amino-5-mercapto-1,2,4-triazole (II). Compound (II) when condensed with various substituted benzaldehydes gives 3–(3–Pyridoxymethylene)–4–(N–substituted benzylidinylamino)–5–mercapto–1,2,4–triazole derivatives. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).
3-Hydroxy pyridine, Mercapto Triazoles, Anti–bacterial, Anti–fungal.
Yogesh Jadhav, Rajeev Varma, Vrushali Patil, A. S. Bobade, S. V. Athlekar, Abhay Chowdhary. Synthesis and Study of Some 1, 2, 4-Triazole derivatives. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1144-1147.
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