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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1122-1124

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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UV-Spectrophotometric Determination of Abacavir Sulphate in Bulk and Tablet Formulations



Address:   Chandrasekaran N.* , Manikanthakumar J., Vengadesh M., Saravanan V.S., Senthil S.P., Mohanraj P. and Kulanthavel T.M.
Department of Pharmaceutical Analysis, the Erode College of Pharmacy and Research Institute, Veppampalayam, Erode 638 112, Tamilnadu.
*Corresponding Author
DOI No:

ABSTRACT:
A new simple, sensitive, precise and economical Spectrophotometric method of analysis for abacavir sulphate both as a bulk and tablet formulation was developed and validated. The method developed with 15 % phosphoric acid and distilled water as solvent. The drug was then estimated at 283 nm. The linear regression analysis data for the calibration plots showed good linear relationship with r2 = 0.9998 in the concentration range 5 - 30 µg/ml. The mean value of correlation coefficient, slope and intercept were 0.9998, 0.032 and 0.0294 respectively. The method was validated for precision, accuracy and recovery studies. LOD and LOQ for Abacavir sulphate were found to be 0.5671 µg/ml and 1.7187 µg/ml respectively. The method has been successfully applied in the analysis of marketed formulations.
KEYWORDS:
Abacavir sulphate; UV Spectrophotometric analysis.
Cite:
Chandrasekaran N. , Manikanthakumar J., Vengadesh M., Saravanan V.S., Senthil S.P., Mohanraj P. , Kulanthavel T.M.;. UV-Spectrophotometric Determination of Abacavir Sulphate in Bulk and Tablet Formulations. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1122-1124.
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