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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1118-1121

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Spectrophotometric Estimation of Drotaverine Hydrochloride and Diclofenac Potassium in Combined Dosage Form



Address:   Snehal S. Ingale, Sumit A. Abnawe, Santosh N. Shinde, Archana S. More, Vishnu P. Choudhari* and Bhanudas S. Kuchekar
Pharmaceutical Analysis and Quality Assurance Department, MAEER’s Maharashtra
Institute of Pharmacy, MIT Campus, Paud Road, Kothrud, Pune, 411038, MS, India.
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, rapid, accurate and economic spectrophotometric methods are described for the determination of Drotaverine Hydrochloride (DRO) and Diclofenac Potassium (DIC) in combined dosage form. The first method is First Derivative and second is Absorption Corrected method. The amplitudes at 248.92 nm and 242.64 in the first derivative spectra were selected to determine Drotaverine Hydrochloride (DRO) and Diclofenac Potassium (DIC), respectively in combined formulation. The second method was based on the absorption corrected method in which DRO and DIC exhibit ?max at 358.41 nm and 277.27 nm, respectively in double distilled water. DRO has some interference due to DIC at 277.27 nm, while DIC do not show any absorption at 358.41 nm. Quantitative estimation of DIC was carried out by subtracting the absorption due to DRO at 277.27 nm using experimentally calculated absorption factor. Beer’s law was obeyed in the concentration range of 8-40 µg mL-1 for DRO and 5-25 µg mL-1 for DIC for both the methods. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed methods which were carried out by following ICH guidelines.
KEYWORDS:
Drotaverine Hydrochloride (DRO), Diclofenac Potassium (DIC), First Derivative Spectrophotometry, Absorption corrected.
Cite:
Snehal S. Ingale, Sumit A. Abnawe, Santosh N. Shinde, Archana S. More, Vishnu P. Choudhari, Bhanudas S. Kuchekar. Simultaneous Spectrophotometric Estimation of Drotaverine Hydrochloride and Diclofenac Potassium in Combined Dosage Form. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1118-1121.
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