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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1061-1063

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Cytotoxic and Antimicrobial Activity of Methanolic Extract of Boerhaavia diffusa L.

Address:   Mukesh Kumar Singh1*, A. Prathapan1, Kushagra Nagori1, S. Ishwarya1 and K.G Raghu2
1Department of Pharmaceutical Biotechnology, SRM University, Chennai, India.
2Biochemistry and Cell Culture Laboratory, Agro processing and Natural Products
Division. National Institute for Interdisciplinary Science and Technology (NIIST) CSIR, Thiruvananthapuram, Kerala, India, 695019.
*Corresponding Author

In the present study, cytotoxic and antimicrobial activities of methanolic extract of Boerhavia diffusa were investigated. The extract was tested against six bacterial species, seven fungi species and two types of yeast. Both stem and leaf extracts of Boerhavia diffusa showed antimicrobial activity in a dose dependant manner (300-1800µg). Leaf extract of Boerhavia diffusa showed maximum antibacterial activity against Staphylococcus aureus sub sp aureus (22 mm) and maximum antifungal activity against Fusarium oxysporum (13 mm). Cytotoxicity of the whole plant extract was assayed in HCT-116 and K-562 cell lines using MTT assay and the extract showed weak cytotoxicity in both of the cell lines.
Boerhaavia diffusa, anti microbial activity, cytotoxic activity, MTT assay.
Mukesh Kumar Singh, A. Prathapan, Kushagra Nagori, S. Ishwarya, K.G Raghu. Cytotoxic and Antimicrobial Activity of Methanolic Extract of Boerhaavia diffusa L. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1061-1063.
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