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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of Taste Masked Fast Disintegrating Tablet of Racecadotril



Address:   Pharmacy Group, Birla Institute of Technology and Science, Pilani. (Rajasthan)
DOI No: Not Available

ABSTRACT:
Racecadotril is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor. racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine. The aim of this study was to prepare, using taste masked granules, rapidly disintegrating tablets of Racecadotril, a bitter drug. The taste masked granules were prepared by solid dispersion technique and with polymeric granulation. In vitro release profile obtained at pH 6.8 indicate that perceivable amount of drug will not be released in saliva while high percent release (more than 75% in 60 min) would be obtained at pH 4.5. These taste masked granules were directly compressed into tablets using sodium starch glycolate as a super-disintegrant. The prepared tablets containing the taste masked granules having sufficient strength of 3.5 kg/cm were evaluated disintegration time, drug content, in-vitro release parameters. Developed formulation is more patient compliance dosage forms.
KEYWORDS:
Racecadotril, Taste masking, solid dispersion, Super-disintegrant.
Cite:
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