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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   1018-1022

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Plant Derived Ribosome Inactivating Proteins: An Overview

Address:   Nitin Kumar, Satyendra Singh, Manvi and Rajiv Gupta*
Department of Pharmacognosy, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow 227 105 U.P (India)
*Corresponding Author

Many plants accumulate proteins that are commonly referred to as ribosome-inactivating proteins (RIPs). Biological effects described to these proteins go back to ancient times because of the high toxicity of seeds of castor bean (Ricinus communis) and jequirity bean (Abrus precatorius), as well as anti-HIV, the abortifacient activity of some plants like Trichosanthes kirilowii and Momordica charantia, rely on the presence of RIPs. Pokeweed antiviral protein, and ricin, previously described as ribosome-inactivating proteins were shown to damage single-stranded DNA by removal of a protein-specific set of adenines. RIPs are enzymes and some have multiple enzymatic activities. These enzymes are expected to damage DNA rather than participate in repair processes. All RIPs depurinated DNA extensively and some released adenine from all adenine-containing polynucleotides. The entire class of plant proteins, called ribosome-inactivating proteins, may be classified as polynucleotide: adenosine glycosidases. The significance of this DNAase activity to the biological function of these plant proteins along with their toxicity effect to animal cells remains to be fully understood.
Ribosome inactivating protein, Trichosanthin, Cytotoxicity, Antiviral protein, Abortifacient.
Nitin Kumar, Satyendra Singh, Manvi, Rajiv Gupta. Plant Derived Ribosome Inactivating Proteins: An Overview. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 1018-1022.
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