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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Estimation of Olmesartan Medoxomil and Hydrochlorothiazide by Spectrophotometry in Tablet Formulation



Address:   1Amrutvahini College of Pharmacy, Sangamner, Dist. Ahmednagar-422608 (M.S) 2A.R.A.College oF Pharmacy, Nagaon, Dhule (MS) 3School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Bhopal-462036 (M.P)
DOI No: Not Available

ABSTRACT:
Two precise, accurate, sensitive spectrophotometric methods has been developed and validated for the simultaneous estimation of Olmesartan Medoxomil (OLM) and Hydrochlorothiazide (HCT) in tablet formulation. In dual wavelength method absorbance difference at 254.8nm and 284nm were considered for estimation of OLM while HCT was estimated as single component at 322 nm. In simultaneous equation method estimation of OLM and HCT was carried out at 249nm and 273.5nm respectively. Regression analysis of beers plots showed good correlation in concentration range of 0-25 µg/ml for OLM and HCT respectively. Accuracy was determined by recovery studies from tablet dosages form and ranges from 98-101%. Precision of method was find out as repeatability, day to day and analyst to analyst variation and shows the values within limit (R.S.D. ≤ 2).
KEYWORDS:
Olmesartan Medoxomil, hydrochlorothiazide, Dual Wavelength Method, Simultaneous Equation Method
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