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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   3

Issue No. :  4

Year :  2010

Pages :   964-969

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Transdermal Immunization: A Recent Tool for Immunization

Address:   Dinesh Mishra1, Anuja Mishra2, Vaibhav Dubey3 and Karunakar Shukla1
1 Mahakal Institute of Pharmaceutical Studies, Ujjain (M.P.) India
2 International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Hyderabad (A.P.) India
3Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar (M.P.) India
*Corresponding Author

Vaccination is one of the most powerful tools available in the ongoing battle against infectious agents. Virtually all recommended immunizations require parenteral administration, and many require a series of injections, therefore, new vaccine delivery methods, specifically alternatives to injections, are being sought. Transdermal immunization (TI) offers a new method for the delivery of vaccines, that relies on the application of antigen with adjuvant onto the outer layer of the skin and subsequent delivery to underlying Langerhans cells that serve as antigen-presenting cells. TI is a needle-free method of vaccine delivery that, will decrease the risk of needle-borne diseases, improve access to vaccination by eliminating the need for trained personnel and sterile equipment, and possibly provide a simple means for multivalent- or multiple boosting immunizations. This review presents various novel approaches for TI that is used alternative to parenteral immunizations.
Transdermal immunization, Langerhans cells, Skin, Vaccination.
Dinesh Mishra, Anuja Mishra, Vaibhav Dubey, Karunakar Shukla. Transdermal Immunization: A Recent Tool for Immunization. Research J. Pharm. and Tech.3 (4): Oct.-Dec.2010; Page 964-969.
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